普萘洛尔治疗婴幼儿血管瘤的临床研究进展

张帅, 曹国颖, 胡欣

中国药学杂志 ›› 2015, Vol. 50 ›› Issue (21) : 1849-1852.

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中国药学杂志 ›› 2015, Vol. 50 ›› Issue (21) : 1849-1852. DOI: 10.11669/cpj.2015.21.003
综 述

普萘洛尔治疗婴幼儿血管瘤的临床研究进展

  • 张帅1,2, 曹国颖1, 胡欣1
作者信息 +

A Literature Review of Propranolol for the Treatment of Infantile Hemangiomas

  • ZHANG Shuai1,2,CAO Guo-ying1,HU Xin1
Author information +
文章历史 +

摘要

血管瘤是一种婴幼儿时期常见的血管肿瘤,治疗方法包括手术、激光、放射治疗和药物治疗等。2008年首次发现普萘洛尔对婴幼儿血管瘤有很好疗效,2014年美国食品药品监督管理局批准盐酸普萘洛尔口服液(HEMANGEOL)用于婴幼儿血管瘤的治疗。笔者对其可能的作用机制、临床疗效和不良反应进行了总结,为合理用药提供支持。

Abstract

Hemangiomas is a kind of common vascular tumors for infants and children. Surgical operation, laser, radiation and medicine are commonly used in its treatment.In 2008, it′s firstly clisovered that propranolo had very good therapeutic effect or infcntile hemangioma. Propranolo oral liquid (HWMANGEOL) was approved for the treatment of infantile hemangioma by FDA in 2014. In this paper, its mechanism, efficacy and safety are reviewed.

关键词

普萘洛尔 / 血管瘤 / 临床评价

Key words

propranolo / hemangiomas / clinical evaluation

引用本文

导出引用
张帅, 曹国颖, 胡欣. 普萘洛尔治疗婴幼儿血管瘤的临床研究进展[J]. 中国药学杂志, 2015, 50(21): 1849-1852 https://doi.org/10.11669/cpj.2015.21.003
ZHANG Shuai,CAO Guo-ying,HU Xin. A Literature Review of Propranolol for the Treatment of Infantile Hemangiomas[J]. Chinese Pharmaceutical Journal, 2015, 50(21): 1849-1852 https://doi.org/10.11669/cpj.2015.21.003
中图分类号: R972   

参考文献

[1] BASELGA E. Past, present, and future of propranolol for hemangiomas of infancy[J]. Actas Dermosifiliogr, 2011, 102(7): 484-486.
[2] MARQUELING A L, OZA V, FRIEDEN I J, et al. Propranolol and infantile hemangiomas four years later: a systematic review[J]. Pediatr Dermatol, 2013, 30(2): 182-191.
[3] LEAUTE-LABREZE C, DUMAS DE LA ROQUE E, HUBICHE T, et al. Propranolol for severe hemangiomas of infancy [J]. N Engl J Med, 2008, 358(24): 2649-2651.
[4] LEAUTE-LABREZE C, SANS-MARTIN V. Infantile hemangioma [J]. Presse Med, 2010, 39(4): 499-510.
[5] DAI Y, HOU F, BUCKMILLER L, et al. Decreased eNOS protein expression in involuting and propranolol-treated hemangiomas [J].Arch Otolaryngol Head Neck Surg, 2012, 138(2): 177-182.
[6] HADASCHIK E, SCHEIBA N, ENGSTNER M, et al. High levels of beta2-adrenoceptors are expressed in infantile capillary hemangiomas and may mediate the therapeutic effect of propranolol [J]. J Cutan Pathol, 2012, 39(9): 881-883.
[7] PREY S, LEAUTE-LABREZE C, PAIN C, et al. Mast cells as possible targets of propranolol therapy: an immunohistological study of beta-adrenergic receptors in infantile haemangiomas [J]. Histopathology, 2014, 65(3): 436-439.
[8] THAIVALAPPIL S, BAUMAN N, SAIEG A, et al. Propranolol-mediated attenuation of MMP-9 excretion in infants with hemangiomas [J]. JAMA Otolaryngol Head Neck Surg, 2013, 139(10): 1026-1031.
[9] PARK Y W, YEOM K B, CHOI J W, et al. Effect of propranolol on the treatment of infantile hemangiomas: a single tertiary center 3-year experience [J]. J Dermatolog Treat, 2014, 25(5): 391-395.
[10] SCHIESTL C, NEUHAUS K, ZOLLER S, et al. Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas [J]. Eur J Pediatr, 2011, 170(4): 493-501.
[11] SONDHI V, PATNAIK S K. Propranolol for infantile hemangioma (PINCH): An open-label trial to assess the efficacy of propranolol for treating infantile hemangiomas and for determining the decline in heart rate to predict response to propranolol[J]. J Pediatr Hematol Oncol, 2013, 35(7): 493-499.
[12] BALMA-MENA A, CHAKKITTAKANDIYIL A, WEINSTEIN M, et al. Propranolol in the management of infantile hemangiomas:clinical response and predictors[J]. J Cutan Med Surg, 2012, 16(3): 169-173.
[13] XIAO Q, LI Q, ZHANG B, et al. Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence [J]. Pediatr Surg Int, 2013, 29(6): 575-581.
[14] RAOL N, METRY D, EDMONDS J, et al. Propranolol for the treatment of subglottic hemangiomas[J]. Int J Pediatr Otorhinolaryngol, 2011, 75(12): 1510-1514.
[15] MAHADEVAN M, CHENG A, BARBER C. Treatment of subglottic hemangiomas with propranolol: initial experience in 10 infants [J]. ANZ J Surg, 2011, 81(6): 456-461.
[16] SANTOS S, TORRELO A, TAMARIZ-MARTEL A, et al. Clinical observations on propranolol use for paediatric airway hemangiomas[J]. Acta Otorrinolaringol Esp, 2010, 61(5): 365-370.
[17] ANDERSON DE MORENO L C, MATT B H, MONTGOMERY G, et al. Propranolol in the treatment of upper airway hemangiomas [J]. Ear Nose Throat J, 2013, 92(4-5): 209-214.
[18] ROSBE K W, SUH K Y, MEYER A K, et al. Propranolol in the management of airway infantile hemangiomas [J]. JAMA Otolaryngol Head Neck Surg, 2010, 136(7): 658-665.
[19] YEN K G, HUSSEIN M A. Oral propranolol in the management of periocular capillary hemangiomas [J].Int Ophthalmol Clin, 2013, 53(3): 143-151.
[20] HAIDER K M, PLAGER D A, NEELY D E, et al. Outpatient treatment of periocular infantile hemangiomas with oral propranolol [J]. J AAPOS, 2010, 14(3): 251-256.
[21] MISSOI T G, LUEDER G T, GILBERTSON K, et al. Oral propranolol for treatment of periocular infantile hemangiomas [J]. Arch Ophthalmol, 2011, 129(7): 899-903.
[22] THEUNISSEN C I, SMITT J H, VAN DER HORST C M. Propranolol versus corticosteroids: what should be the treatment of choice in infantile hemangiomas[J]. Ann Plast Surg, 2013, 74(2): 237-241.
[23] HOORNWEG M J, SAEED P, TANCK M W, et al. Comparison of intralesional corticosteroid and propranolol treatment of periorbital infantile hemangiomas: an outcome study of 61 cases [J]. Eur J Ophthalmol, 2014, 24(6): 940-947.
[24] HAIDER K M, NEELY D E, PLAGER D A. Hemangiomas treated with propranolol: do the rewards outweigh the risks[J]. Am Orthopt J, 2013, 63: 2-5.
[25] BERTRAND J, MCCUAIG C, DUBOIS J, et al. Propranolol versus prednisone in the treatment of infantile hemangiomas: a retrospective comparative study [J]. Pediatr Dermatol, 2011, 28(6): 649-654.
[26] BAUMAN N M, MCCARTER R J, GUZZETTA P C, et al. Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial [J]. JAMA Otolaryngol Head Neck Surg, 2014, 140(4): 323-330.
[27] GU M Z, WU J L, ZHAO L M, et al. Controlling therapy with propranolol for infants with parotid gland hemangiomas[J]. Chin J Otorhinolaryngol(中华耳鼻喉头颈外科杂志), 2013, 48(9): 769-770.
[28] GRECO A, D′ERME A M, ZAMMA GALLARATI B, et al. A further experience of propranolol for severe infantile hemangiomas of the face: an observational study [J]. Dermatol Ther, 2014, 27(4): 198-202.
[29] BEN-AMITAI D, HALACHMI S, ZVULUNOV A, et al. Hemangiomas of the nasal tip treated with propranolol [J]. Dermatology, 2012, 225(4): 371-375.
[30] BOSEMANI T, PUTTGEN K B, HUISMAN T A, et al. Multifocal infantile hepatic hemangiomas--imaging strategy and response to treatment after propranolol and steroids including review of the literature [J]. Eur J Pediatr, 2012, 171(7): 1023-1028.
[31] CAVALLI R, NOVOTNA V, BUFFON R B, et al. Multiple cutaneous and hepatic infantile hemangiomas having a successful response to propranolol as monotherapy at neonatal period [J]. G Ital Dermatol Venereol, 2013, 148(5): 525-530.
[32] LV M M, FAN X D, SU L X. Propranolol for problematic head and neck hemangiomas: an analysis of 37 consecutive patients [J]. Int J Pediatr Otorhinolaryngol, 2012, 76(4): 574-578.
[33] HONG P, TAMMAREDDI N, WALVEKAR R, et al. Successful discontinuation of propranolol for infantile hemangiomas of the head and neck at 12 months of age [J]. Int J Pediatr Otorhinolaryngol, 2013, 77(7): 1194-1197.
[34] FRIDMAN G, GRIESER E, HILL R, et al. Propranolol for the treatment of orbital infantile hemangiomas [J]. Ophthal Plast Reconstr Surg, 2011, 27(3): 190-194.
[35] MIQUEL J, BRUNEAU B, DUPUY A. Successful treatment of multifocal intracerebral and spinal hemangiomas with propranolol [J]. J Am Acad Dermatol, 2014, 70(4): 83-84.
[36] XU G Q, LV R R, ZHAO Z F, et al. Topical propranolol for treatment of superficial infantile hemangiomas [J]. J Am Acad Dermatol, 2012, 67(6): 1210-1213.
[37] WANG L, XIA Y, ZHAI Y, et al. Topical propranolol hydrochloride gel for superficial infantile hemangiomas [J]. J Huazhong Univ Sci Technolog Med Sci(华中科技大学学报 医学英德文版), 2012, 32(6): 923-926.
[38] NIU J N, XU G Q, LU R R, et al. Treatment of superficial infantile hemangiomas with topical propranolol[J]. Chin J Plast Surg(中华整形外科杂志), 2013, 29(2): 100-103.
[39] SAINT-JEAN M, LEAUTE-LABREZE C, MAZEREEUW-HAUTIER J, et al. Propranolol for treatment of ulcerated infantile hemangiomas [J]. J Am Acad Dermatol, 2011, 64(5): 827-832.
[40] KIM L H, HOGELING M, WARGON O, et al. Propranolol: Useful therapeutic agent for the treatment of ulcerated infantile hemangiomas [J]. J Pediatr Surg, 2011, 46(4): 759-763.
[41] KOAY A C, CHOO M M, NATHAN A M, et al. Combined low-dose oral propranolol and oral prednisolone as first-line treatment in periocular infantile hemangiomas [J]. J Ocul Pharmacol Ther, 2011, 27(3): 309-311.
[42] REDDY K K, BLEI F, BRAUER J A, et al. Retrospective study of the treatment of infantile hemangiomas using a combination of propranolol and pulsed dye laser [J]. Dermatol Surg, 2013, 39(6): 923-933.
[43] ZEGPI-TRUEBA M S, ABARZUA-ARAYA A, SILVA-VALENZUELA S, et al. Oral propranolol for treating infantile hemangiomas: a case series of 57 patients [J]. Actas Dermosifiliogr, 2012, 103(8): 708-717.
[44] HEMANGEOL-Drug Description [EB/OL]. RxList,2004[2014-04-03]: http://www.rxlist.com/hemangeol-drug.htm.
[45] ZAHER H, RASHEED H, ESMAT S, et al. Propranolol and infantile hemangiomas: different routes of administration, a randomized clinical trial [J]. Eur J Dermatol, 2013, 23(5):646-652.
[46] ZHAI Y N, SONG H T, CHEN S Q, et al. Effect of propranolol gel on infantile hemangiomas [J].Chin J Plast Surg(中华整形外科杂志), 2013, 29(1): 25-28.
[47] JIAN D, CHEN X, BABAJEE K, et al. Adverse effects of propranolol treatment for infantile hemangiomas in China [J]. J Dermatolog Treat, 2014, 25(5): 388-390.
[48] SHEPHERD D, ADAMS S, WARGON O, et al. Childhood wheeze while taking propranolol for treatment of infantile hemangiomas [J]. Pediatr Pulmonol, 2012, 47(7): 713-715.
[49] PUTTGEN K B, SUMMERER B, SCHNEIDER J, et al. Cardiovascular and blood glucose parameters in infants during propranolol initiation for treatment of symptomatic infantile hemangiomas [J]. Ann Otol Rhinol Laryngol, 2013, 122(9): 550-554.
[50] ERBAY A, SARIALIOGLU F, MALBORA B, et al. Propranolol for infantile hemangiomas: a preliminary report on efficacy and safety in very low birth weight infants [J]. Turk J Pediatr, 2010, 52(5): 450-456.
[51] BAGAZGOITIA L, HERNANDEZ-MARTIN A, TORRELO A. Recu-rrence of infantile hemangiomas treated with propranolol[J]. Pediatr Dermatol, 2011, 28(6): 658-662.
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